Division of Clinical Pharmacology
| Head of Division | Prof. Juliana CN Chan, Professor of Medicine and Therapeutics |
| Academic Staff |
Prof. Brian Tomlinson, Clinical Professor (honorary) Prof. Elaine YK Chow, Associate Professor (Clinical) Dr. Jones CM Chan, Clinical Associate Professor (honorary) Dr. Raymond SM Wong, Clinical Associate Professor (honorary) Prof. Juliana NM Lui, Research Assistant Professor Prof. Aimin Yang, Research Assistant Professor Dr. Edith WK Chow, Clinical Lecturer Dr. Tony CK O, Clinical Lecturer |
| Research Staff | Dr. Benny SP Fok, Scientific Officer Dr. Natural HS Chu, Post-doctoral Fellow Dr. James Ling, Post-doctoral Fellow Dr. Jiazhou Yu, Post-doctoral Fellow Dr. Stephanie HM Cheung, Research Associate Dr. Baoqi Fan, Research Associcate Dr. Phyllis SF Kwong, Research Associate Dr. Eric SH Lau, Research Associate Dr. Leon M Shi, Research Associate Ms. Abby Qiaoyi Li, Research Assistant Ms. Ally MW Chan, Junior Research Assistant Ms. Renee SY Tse, Junior Research Assistant (Part-time) Ms. Emily WM Poon, Technician Ms. Angel OK Tam, Research Nurse Ms. Eliza CY Choy, Research Nursing Officer (Part-time) Ms. SL Kong, Research Nursing Officer (Part-time) Ms. Winnie MN Yeung, Research Nursing Officer (Part-time) Ms. Swen YW Ip, Research Nurse (Part-time) Ms. April WY Lai, Research Nurse (Part-time) |
| Postgraduate Student | Ms. Zhengli Bai Ms. Yanrong Du Ms. Yanting Huang Ms. Kelly TC Wong (part-time) Mr. Yincong Xue Ms. Minglu Zhang |
| Administrative Staff | Ms. Vivian MW Chu, General Clerk II Ms. Maggie OK Lee, Clerical Assistant |
Research, Education and Care Facilities (Prince of Wales Hospital)
- Diabetes Clinical Research Unit, Ward 3M, Day Treatment Block and Children Ward
- Hong Kong Institute of Diabetes and Obesity (http://hkido.cuhk.edu.hk/)
- Phase 1 Clinical Trial Centre (https://www.p1ctc.med.cuhk.edu.hk/en-us/home.aspx)
- Clinical Research Management Office (https://www.crmo.med.cuhk.edu.hk/en/)
- Poisons Treatment Centre (https://www.hkpcn.org.hk/eng/PTC_staff.html)
- Asia Diabetes Foundation (https://www.adf.org.hk/)
Research Interests
- Pharmacoepidemiology and pharmacogenetic analysis of mature and novel therapeutic agents in the prevention and treatment of metabolic syndrome, diabetes, cardiovascular-renal disease and cancer
- Pathophysiology, prediction, prevention and personalized care with precision in young-onset diabetes and diabetic kidney disease
- Development and evaluation of technology and therapeutics in the field of metabolic syndrome, prediabetes, type 1 and type 2 diabetes and its complications including continuous glucose monitoring system and drug delivery system
- Early to late phase clinical trials on the efficacy, safety and acceptability of Western and Chinese medicines and alternative therapeutics in the field of prediabetes, diabetes and its comorbidities including cardiovascular-renal disease and cancer
- Patient reported outcomes, quality of life and cost-effectiveness analysis of therapeutic agents and interventions for prevention and treatment of diabetes and cardiovascular-renal-cancer diseases
Selected Publications
- Yang A, Shi M, Lau ESH, Wu H, Zhang X, Fan B, Kong APS, Luk AOY, Ma RCW, Chan JCN, Chow E. Clinical outcomes following discontinuation of renin-angiotensin-system inhibitors in patients with type 2 diabetes and advanced chronic kidney disease: A prospective cohort study. EClinicalMedicine 2023;55:101751
https://www.ncbi.nlm.nih.gov/pubmed/36457651 - Chow E, Chan JCN. The emerging role of incretins and twincretins. Nature reviews Endocrinology 2022;18:73-74
https://www.ncbi.nlm.nih.gov/pubmed/34873288 - Chow E, Wang K, Lim CKP, Tsoi STF, Fan B, Poon E, Luk AOY, Ma RCW, Ferrannini E, Mari A, Chen L, Chan JCN. Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes. Diabetes 2023;72:299-308
https://pubmed.ncbi.nlm.nih.gov/36342518/ - Mao D, Lau ESH, Wu H, Yang A, Shi M, Fan B, Tam CHT, Chow E, Kong APS, Ma RCW, Luk A, Chan JCN. Risk associations of long-term HbA1c variability and obesity on cancer events and cancer-specific death in 15,286 patients with diabetes - A prospective cohort study. The Lancet Regional Health - Western Pacific 2022;18:100315
https://doi.org/10.1016/j.lanwpc.2021.100315 - Yang A, Lau ESH, Wu H, Ma RCW, Kong APS, So WY, Luk AOY, Fu AWC, Chan JCN, Chow E. Attenuated Risk Association of End-Stage Kidney Disease with Metformin in Type 2 Diabetes with eGFR Categories 1-4. Pharmaceuticals 2022;15:1140
https://www.mdpi.com/1424-8247/15/9/1140 - Fan B, Wu H, Shi M, Yang A, Lau ESH, Tam CHT, Mao D, Lim CKP, Kong APS, Ma RCW, Chow E, Luk AOY, Chan JCN. Associations of the HOMA2-%B and HOMA2-IR with Progression to Diabetes and Glycaemic Deterioration in Young and Middle-aged Chinese. Diabetes/metabolism research and reviews 2022:e3525
https://www.ncbi.nlm.nih.gov/pubmed/35174618 - Chu N, Chan JCN, Chow E. Pharmacomicrobiomics in Western Medicine and Traditional Chinese Medicine in Type 2 Diabetes. Front Endocrinol (Lausanne) 2022;13:857090
https://www.ncbi.nlm.nih.gov/pubmed/35600606 - Ling J, Ng J, Lau ESH, Ma RCW, Kong APS, Luk AOY, Kwok JSS, Szeto CC, Chan JCN, Chow E. Continuous Glucose Monitoring Metrics in the Assessment of Glycemia in Moderate-to-Advanced CKD in Diabetes. Kidney Int Rep 2022;7:1354-1363
https://www.ncbi.nlm.nih.gov/pubmed/35685309 - Yang A, Wu H, Lau ESH, Zhang X, Shi M, Fan B, Ma RCW, Kong APS, Luk AOY, Chan JCN, Chow E. Glucose-lowering drug use, glycemic outcomes, and severe hypoglycemia: 18-Year trends in 0·9 million adults with Diabetes in Hong Kong (2002–2019). The Lancet Regional Health - Western Pacific 2022;26:10050
https://doi.org/10.1016/j.lanwpc.2022.100509 - Wang K, Yang A, Shi M, Tam CCH, Lau ESH, Fan B, Lim CKP, Lee HM, Kong APS, Luk AOY, Tomlinson B, Ma RCW, Chan JCN, Chow E. CYP2C19 Loss-of-function Polymorphisms are Associated with Reduced Risk of Sulfonylurea Treatment Failure in Chinese Patients with Type 2 Diabetes. Clinical pharmacology and therapeutics 2021;111:461-469
https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2446 - Chan JCN, Lim LL, Wareham NJ, Shaw JE, Orchard TJ, Zhang P, Lau ESH, Eliasson B, Kong APS, Ezzati M, Aguilar-Salinas CA, McGill M, Levitt NS, Ning G, So WY, Adams J, Bracco P, Forouhi NG, Gregory GA, Guo J, Hua X, Klatman EL, Magliano DJ, Ng BP, Ogilvie D, Panter J, Pavkov M, Shao H, Unwin N, White M, Wou C, Ma RCW, Schmidt MI, Ramachandran A, Seino Y, Bennett PH, Oldenburg B, Gagliardino JJ, Luk AOY, Clarke PM, Ogle GD, Davies MJ, Holman RR, Gregg EW. The Lancet Commission on diabetes: using data to transform diabetes care and patient lives. Lancet 2021;396:2019-2082
https://www.thelancet.com/commissions/diabetes - Mao D, Tian XY, Mao D, Hung SW, Wang CC, Lau CBS, Lee HM, Wong CK, Chow E, Xing M, Cao H, Ma RC, Chan PKS, Kong APS, Li JJX, Rutter GA, Tam WH, Chan JCN. A polysaccharide extract from the medicinal plant Maidong inhibits the IKK-NF-kappaB pathway and IL-1beta-induced islet inflammation and increases insulin secretion. The Journal of biological chemistry 2020;295:12573-12587
https://www.ncbi.nlm.nih.gov/pubmed/32605924 - Yang A, Wu H, Lau ESH, Ma RCW, Kong APS, So WY, Luk AOY, Chan JCN, Chow E. Trends in Glucose-Lowering Drug Use, Glycemic Control, and Severe Hypoglycemia in Adults With Diabetes in Hong Kong, 2002-2016. Diabetes care 2020;43:2967-2974
https://www.ncbi.nlm.nih.gov/pubmed/33046501 - Chan JCN, Lim LL, Luk AOY, Ozaki R, Kong APS, Ma RCW, So WY, Lo SV. From Hong Kong Diabetes Register to JADE Program to RAMP-DM for Data-Driven Actions. Diabetes care 2019;42:2022-2031
https://www.ncbi.nlm.nih.gov/pubmed/31530658 - Zhao HL, Sui Y, Qiao CF, Yip KY, Leung RK, Tsui SK, Lee HM, Wong HK, Zhu X, Siu JJ, He L, Guan J, Liu LZ, Xu HX, Tong PC, Chan JC. Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression. Diabetes 2012;61:933-943
http://www.ncbi.nlm.nih.gov/pubmed/22396199
